Preliminary Screening Choices for PTC 

Murphy’s Laws runs somewhat like “if anything can go wrong it certainly will”. That law certainly applies to synthesis research and process development. When you try your first phase transfer catalysis (PTC) reaction you may avoid disappointments by considering a few essential parameters. PTC reactions can be tricky, so remember to be patient: do not expect a breakthrough immediately and know that optimizing efforts will have to follow your preliminary screening efforts.